A recent study discovered that low-dose acetylsalicylic acid, popularly known as aspirin, can attenuate inflammatory responses to sleep deprivation. Study is to be presented at the SLEEP 2024 annual meeting.
The results suggest that prior treatment of low-dose aspirin during sleep restriction lowered pro-inflammatory responses compared to a placebo. Aspirin specifically reduced interleukin-6 expression, COX-1/COX-2 double positive cells in lipopolysaccharide-stimulated monocytes, and C-reactive protein serum levels.
“The novelty of this study is that it investigated whether we can pharmacologically reduce the inflammatory consequences of sleep restriction,” said lead author Larissa Engert, who has a doctorate in behavioral physiology and is a postdoctoral fellow in the department of neurology at Beth Israel Deaconess Medical Center and the division of sleep medicine at Harvard Medical School in Boston. “We used a non-steroidal, anti-inflammatory drug because it has been shown to affect specific inflammatory pathways, which were previously shown to be dysregulated by experimental sleep restriction or sleep disturbances.”
The researchers collected data from 46 healthy adults in a randomized placebo-controlled crossover trial with three protocols – sleep restriction/aspirin, sleep restriction/placebo, and control sleep/placebo – each consisting of a 14-day at-home phase followed by an 11-day in-hospital stay. In the sleep restriction/aspirin condition, participants took low-dose aspirin during the at-home phase and in-hospital stay. Each in-hospital stay started with two nights of an eight-hour sleep opportunity. Then, under the sleep restriction conditions, participants were exposed to five nights of a four-hour sleep opportunity, followed by three nights of recovery sleep. The control sleep condition provided an eight-hour sleep opportunity throughout the in-hospital stay. Sleep and immunologic measures were assessed at baseline and various points throughout the study. Source: ANI