WASHINGTON (TIP): President Barack Obama secured a landmark foreign policy victory over ferocious opposition from Republicans and the government of Israel when Democratic Sen Barbara Mikulski became the 34th vote in favor of the Iran nuclear deal.

Mikulski’s backing gives supporters the margin they need to uphold an expected Obama veto of a congressional resolution of disapproval that Republicans hope to pass later this month.

And it spells failure for opponents of the international agreement who sought to foil it by turning Congress against it.

Leading that effort were Israel and its allies in the US, who failed to get traction after spending millions of dollars trying.

The agreement signed by Iran, the US and five other world powers limits Iran’s nuclear program in exchange for relief from hundreds of billions of dollars in sanctions.

Republicans and Israeli leaders contend that concessions made to Iran could empower that country, which has sworn to destroy Israel.

“No deal is perfect, especially one negotiated with the Iranian regime,” Mikulski said in a statement. “I have concluded that this Joint Comprehensive Plan of Action is the best option available to block Iran from having a nuclear bomb. For these reasons, I will vote in favor of this deal.” Secretary of State John Kerry is sending a letter to all members of Congress outlining U.S. security commitments to Israel and the Gulf Arab states in light of the nuclear deal. The letter comes as Kerry delivers a major policy speech Wednesday in Philadelphia that focuses on how the international agreement makes the US and its allies safer and how the deal is being mischaracterized by some opponents. “I really believe the fastest way to a genuine arms race in the Middle East is to not have this agreement,” Kerry said in a nationally broadcast interview on Sept 2.